Проведен анализ по нахождению генов гомосексуальности среди баз данных 23andMe и UK Biobank с участием геномов 350 тыс человек.
Спойлер: по-прежнему неясно, хотя и возможно предсказать сексуальное поведение по алгоритму.
Предложили гипотезу опережающего размножения.
Ничто не ново под Луной, так что номогенез вернулся.
Genetic patterns offer clues to evolution of homosexuality
Massive study finds that genetic markers associated with same-sex encounters might aid reproduction. But some scientists question the conclusions.
To evolutionary biologists, the genetics of homosexuality seems like a paradox. In theory, humans and other animals who are exclusively attracted to others of the same sex should be unlikely to produce many biological children, so any genes that predispose people to homosexuality would rarely be passed on to future generations. Yet same-sex attraction is widespread in humans, and research suggests that it is partly genetic.
In a study of data from hundreds of thousands of people, researchers have now identified genetic patterns that could be associated with homosexual behaviour, and showed how these might also help people to find different-sex mates, and reproduce. The authors say their findings, published on 23 August in Nature Human Behaviour1, could help to explain why genes that predispose people to homosexuality continue to be passed down. But other scientists question whether these data can provide definitive conclusions.
Evolutionary geneticist Brendan Zietsch at the University of Queensland in Brisbane, Australia, and his colleagues used data from the UK Biobank, the US National Longitudinal Study of Adolescent to Adult Health and the company 23andMe, based in Sunnyvale, California, which sequence genomes and use questionnaires to collect information from their participants. The team analysed the genomes of 477,522 people who said they had had sex at least once with someone of the same sex, then compared these genomes with those of 358,426 people who said they’d only had heterosexual sex. The study looked only at biological sex, not gender, and excluded participants whose gender and sex did not match.
In earlier research, the researchers had found that people who’d had at least one same-sex partner tended to share patterns of small genetic differences scattered throughout the genome2. None of these variations seemed to greatly affect sexual behaviour on its own, backing up previous research that has found no sign of a ‘gay gene’. But the collection of variants seemed to have a small effect overall, explaining between 8% and 25% of heritability.
Next, the researchers used a computer algorithm to simulate human evolution over 60 generations. They found that the array of genetic variations associated with same-sex behaviour would have eventually disappeared, unless it somehow helped people to survive or reproduce.
Zietsch and his team decided to test whether these genetic patterns might provide an evolutionary edge by increasing a person’s number of sexual partners. They sorted the participants who had only had heterosexual sex by the number of partners they said they had had, and found that those with numerous partners tended to share some of the markers that the team had found in people who had had a same-sex partner.
The researchers also found that people who’d had same-sex encounters shared genetic markers with people who described themselves as risk-taking and open to new experiences. And there was a small overlap between heterosexual people who had genes linked to same-sex behaviour and those whom interviewers rated as physically attractive. Zietsch suggests that traits such as charisma and sex drive could also share genes that overlap with same-sex behaviour, but he says that those traits were not included in the data, so “we’re just guessing”.The authors acknowledge many limitations of the study. All of the participants lived in the United Kingdom or United States, and were of European descent. And the databases’ questionnaires asked about sexual behaviour, not sexual attraction. Most of the participants were born during a time when homosexuality was either illegal or culturally taboo in their countries, so many people who were attracted to others of the same sex might never have actually acted on their attraction, and could therefore have ended up in the wrong group in the study.